The WBFS (Wii Backup File System) format is a file system used for backing up Wii games. The WBFS format allows for storing and playing Wii games from a hard drive or other storage device, rather than from the original game disc.
The NTSC release is often cited as having slightly different resource drops, with a higher prevalence of money over ammo in certain sections. Understanding the WBFS Format Resident Evil 4: Wii Edition - PAL vs NTSC - GameFAQs resident evil 4 wii edition wbfs ntsc exclusive